Genomic coordinate 7:141,972,631
Here I present: “Taste Receptors”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PTC) 味覺感受器。icd10=R43.9
INTRODUCTION.
The sense of bitter taste is mediated by a group of bitter taste receptor proteins that reside on the surface of taste cells within the taste buds of the tongue. These proteins are 7-transmembrane domain, G protein-coupled receptors that are encoded by the TAS2R gene family which contains at least 25 functional genes.
Humans worldwide display a bimodality in sensitivity to the bitter taste of phenylthiocarbamide (PTC), with approximately 75% of individuals perceiving it as intensely bitter, whereas the rest perceive it as tasteless. This difference has been the basis of study of taste perception in humans for over 70 years.
Propylthiouracil (PROP) and phenylthiocarbamide (PTC) are members of a class of compounds known as thioureas. The compounds carry the chemical group N-C=S, which is responsible for their characteristic bitter taste.
There is evidence of five (5) haplotypes arising from 3 coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of phenylthiocarbamide (PTC) taste sensitivity. Taste receptor, type-2, member-38 (TAS2R38) is encoded on cytogenetic location 7q34 and genomic coordinates 7:141,972,631-141,973,773. The screenshot of TAS2R38 1,143 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides TAS2R38 in the 7q34 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:141,764,097 | TAS2R3 | Taste receptor type 2, member 3 |
| 7:141,776,674 | TAS2R4 | Taste receptor type 2, member 4 |
| 7:141,790,217 | TAS2R5 | Taste receptor type 2, member 5 |
| 7:141,927,357 | CLEC5A | C-type lectin domain family 5, member A |
| 7:141,972,631 | TAS2R38 | Taste receptor, type 2, member 38 |
| 7:141,986,518 | MGAM | Maltase-glucoamylase |
| 7:142,749,472 | PRSS1 | Protease, serine, 1 (trypsin 1) |
| 7:142,770,970 | PRSS2 | Protease, serine, 2 (trypsin 2) |
| 7:142,786,213 | TRBD1 | T-cell receptor beta chain diversity gene 1 |
| 7:142,791,694 | TRBC1 | T-cell receptor beta chain constant region 1 |
