Here I present: “Juvenile Parkinson’s Disease”, Victor McKusick, Mendelian Inheritance in Man’, (JPD) 青少年帕金森病。1966. icd10=20
INTRODUCTION.
Juvenile Parkinson’s disease (JPD) is a movement disorder that presents before the age of 21 years.
There is evidence that autosomal recessive juvenile Parkinson disease (JPD) is caused by homozygous or compound heterozygous mutation in the parkin (PRKN) gene on cytogenetic location 6q26 and genomic coordinates 6:161,347,417-162,727,766. The screenshot of the PRKN gene 1,380,350 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PRKN in the 6q26 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:160,600,001 | MRT28 | Intellectual developmental disorder, autosomal recessive 28 |
| 6:160,702,193 | PLG | Plasminogen |
| 6:160,991,769 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 |
| 6:161,129,967 | AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
| 6:161,347,417 | PRKN | Parkin RBR E3 ubiquitin protein ligase |
| 6:162,727,132 | PACRG | Parkin coregulated gene |
| 6:163,413,065 | CAHM | Colorectal adenocarcinoma hypermethylated gene, noncoding |
| 6:163,414,718 | QKI | QKI, KH domain-containing RNA-binding protein |
| 6:164,100,001 | CHDM | Chordoma |
| 6:164,100,001 | KAZA3 | Kala-azar, susceptibility to, 3 |
