Here I present: “Hereditary Haemochromatosis”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HH) 遺傳性血色素。icd10=E83.110
INTRODUCTION.
Hereditary haemochromatosis (HH) is a genetic disorder characterized by excessive intestinal absorption of dietary iron resulting in a pathological increase in total body iron stores. Humans have no mechanism to regulate excess iron, simply losing a limited amount through various means like sweating or menstruating.
There is evidence hereditary hemochromatosis type-1 (HFE1) is caused by homozygous or compound heterozygous mutation in the homeostatic iron regulator (HFE) gene on cytogenetic location 6p22.2 and genomic coordinates 6:26,087,429-26,098,343 . The screenshot of the HFE gene 10,915 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides HFE in the 6p22.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:26,033,092 | H2AC4 | H2A clustered histone 4 |
| 6:26,043,227 | H2BC3 | H2B clustered histone 3 |
| 6:26,045,384 | H3C3 | H3 clustered histone 3 |
| 6:26,055,740 | H1-2 | H1.2 linker histone, cluster member |
| 6:26,087,429 | HFE | Homeostatic iron regulator |
| 6:26,103,933 | H4C3 | H4 clustered histone 3 |
| 6:26,107,412 | H1-6 | H1.6 linker histone, cluster member |
| 6:26,113,170 | H2BC4 | H2B clustered histone 4 |
| 6:26,124,172 | H2AC6 | H2A clustered histone 6 |
| 6:26,156,329 | H1-4 | H1.4 linker histone, cluster member |
