Here I present: “Leukemia Pre-B Cell Transcription-Factor”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PBX2) 白血病前B細胞轉錄因子。icd10=C91.10
INTRODUCTION.
Regulator of pre-B-cell leukemia transcription factors function inhibits the binding of PBX2-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX2, tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
There is evidence leukemia pre-B cell transcription factor (PBX2) gene is encoded on cytogenetic location 6p21.32 and genomic coordinates 6:32,184,733-32,190,202. The screenshot of the PBX2 gene 5,470 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PBX2 in the 6p21.32 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:32,164,595 | EGFL8 | Epidermal growth factor-like 8 |
| 6:32,168,212 | AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 |
| 6:32,178,405 | RNF5 | RING finger protein-5 |
| 6:32,180,969 | AGER | Advanced glycosylation end product-specific receptor |
| 6:32,184,733 | PBX2 | Pre-B-cell leukemia transcription factor-2 |
| 6:32,190,766 | GPSM3 | G-protein signaling modulator 3 |
| 6:32,194,843 | NOTCH4 | Notch, Drosophila, homolog of, 4 |
| 6:32,292,698 | TSBP1 | Testis-expressed basic protein 1 |
| 6:32,393,339 | BTNL2 | Butyrophilin-like protein 2 |
| 6:32,439,887 | HLA-DRA | Major histocompatibility complex, class II, DR alpha |
