Here I present: “Pituitary Tumor-Transforming Gene”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 垂體腫瘤轉化基因。 (PTTG1).
INTRODUCTION.
Securin is a protein encoded by the Pituitary Tumor-Transforming Gene (PTTG1).
Securin is a protein that is crucial for the stability of the cells’ genome. By preventing premature sister-chromatid separation during mitosis, securin is involved in the regulation of accurate cell cycle progression.
There is evidence that pituitary tumor-transforming gene (PTTG1) is encoded on cytogenetic location 5q33.3 and genomic coordinates 5:160,421,855-160,428,744. The screenshot of the PTTG1 gene 6,890 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PTTG1 in the 5q33.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 5:160,187,381 | FABP6 | Fatty acid-binding protein 6, ileal (gastrotropin) |
| 5:160,347,754 | C1QTNF2 | C1q- and TNF-related protein 2 |
| 5:160,393,148 | ZBED8 | Zinc finger BED-type containing 8 |
| 5:160,401,641 | SLU7 | SLU7 homolog, splicing factor |
| 5:160,421,855 | PTTG1 | PITG1 regulator, securin |
| 5:160,485,352 | MIR146A | Micro RNA 146A |
| 5:160,500,001 | NIDDM4 | Diabetes mellitus, noninsulin-dependent, 4 |
| 5:160,563,120 | ATP10B | ATPase, phospholipid-transporting, 10B |
| 5:161,288,436 | GABRB2 | Gamma-aminobutyric acid (GABA) A receptor, beta-2 |
| 5:161,685,721 | GABRA6 | Gamma-aminobutyric acid (GABA) A receptor, alpha-6 |
