“Sjogren Syndrome Antigen”, Victor McKusick, Mendelian Inheritance in Man, 1966.

Here I present: “Sjogren Syndrome Antigen”, Victor McKusick, Mendelian Inheritance in Man’, 1966.

INTRODUCTION.

Sjögren syndrome is an autoimmune disease that primarily affects the body’s exocrine glands, particularly the lacrimal and salivary glands. Common symptoms include: dry mouth, dry eyes and often seriously affects other organ systems, such as the lungs, kidneys, and nervous system.

There is evidence that Sjögren syndrome is associated TROVE domain family, member-2 (TROVE2) with the mutation of the Y-RNA binding protein (RO60) gene on cytogenetic location 1q31.2 and genomic coordinates 1:193,059,612-193,091,777 . The screenshot of the RO60 gene 32,166 bp (base pairs) of DNA sequence length is shown BELOW.  Nine (9) other genes besides RO60 in the 1q31.2 cytogenetic location are listed BENEATH.