IDC10 Classification = L85.1
Genomic coordinate (human 12:52,674,736 KRT1) & (human 12:49,961,872 AQP5).
Cytoband (human 12q13.13 KRT1) & (human 12q13.12 AQP5).
Cytogenetic Classification = Chromosome-12 C-group.
Topological Classification is Hyperbolic Umbilic Chromosome-12 of 1,200 genes.
Here I 🎁 present: “Palmoplantar Keratoderma”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Keratoderma is a broad term for marked thickening of the skin’s outer layer, primarily affecting the palms of the hands and soles of the feet (palmoplantar keratoderma ). It is caused by an overproduction of keratin and can be either inherited or acquired due to underlying medical conditions, medications, or environmental friction.
Types of Keratoderma.
Diffuse: Affects large, uniform areas across most of the palms and soles.
Focal/Striate: Thickened skin mainly localized to pressure points or linear bands on the hands and feet.
Punctate: Results in tiny, hard, wart-like bumps or “spikes” scattered across the palms and soles.
Causes.
Hereditary: Passed down genetically due to mutations that affect the skin’s structural proteins.
Acquired: Can develop from chronic friction, fungal infections, inflammatory skin conditions (like psoriasis or eczema), nutritional deficiencies, or as a rare side effect of certain medications or internal malignancies.
Symptoms.
Symptoms typically involve waxy, hardened, yellow, or scaly skin that is prone to deep, painful fissures or cracks that may bleed and make walking or grasping objects difficult.
