Genomic coordinate 9:136,977,504
Here I present: “Brain prostaglandin D2 synthase”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PDGDS) 腦前列腺素D2合成酶。icd10=G93.89
INTRODUCTION.
Brain Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin-H2 (PGH2) into prostaglandin-D2 (PGD2), a crucial neuromodulator in the brain. PGD2 is involved in regulating sleep, body temperature, and other functions. PTGDS is a member of the lipocalin superfamily and is the primary source of PGD2 in the central nervous system, where it is secreted into the cerebrospinal fluid (CFS).
There is evidence that the brain prostaglandin D2 synthase (PTGDS) gene is encoded on cytogenetic location 9q34.3 and genomic coordinate 9:136,977,504 . Prostaglandin D2 (PGD2) functions as a neuromodulator and/or trophic factor in the central nervous system. Glutathione (GSH)-independent PGD synthase catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2 in the presence of various sulfhydryl compounds. The enzyme is responsible for biosynthesis of PGD2 in the brain.
