Genomic coordinate 8:142,449,649
Here I present: “Brain-specific Angiogenesis Inhibitor”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 腦特異性血管生成抑制。icd10=Z79.63
INTRODUCTION.
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis.
Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis, vessel elongation and vessel cooption also play a role.
Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors, and from neovascularization. The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease.
Angiogenesis is controlled by a local balance between stimulators and inhibitors of growth of new vessels and is suppressed under normal physiologic conditions. Adhesion G protein-coupled receptor-B1 (ADGRB1) is postulated to be an inhibitor of angiogenesis. The ADGRB1 gene is encoded on cytogenetic location 8q24.3 and genomic coordinates 8:142,449,649-142,545,007. The screenshot of the ADGRB1 gene 95,359 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ADGRB1 in the 8q24.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 8:141,207,174 | SLC45A4 | Solute carrier family 45, member 4 |
| 8:141,356,470 | GPR20 | G protein-coupled receptor-20 |
| 8:141,392,021 | PTP4A3 | Protein-tyrosine phosphatase, type 4A, 3 |
| 8:142,212,080 | TSNARE1 | T-snare domain-containing protein 1 |
| 8:142,449,649 | ADGRB1 | Adhesion G protein-coupled receptor B1 |
| 8:142,611,049 | ARC | Activity-regulated cytoskeleton-associated protein |
| 8:142,643,682 | JRK | JRK helix-turn-helix protein |
| 8:142,670,297 | PSCA | Prostate stem cell antigen |
| 8:142,700,111 | LY6K | Lymphocyte antigen 6 complex, locus K |
| 8:142,740,949 | SLURP1 | Secreted LY6/uPAR-related protein 1 |
