Here I present: “Coronary Artery Spasm”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 冠狀動脈痙攣。icd10=I25.111
INTRODUCTION.
Coronary artery spasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion.
When coronary artery spasm occurs, the occlusion temporarily produces ischemia. A wide array of symptoms or presentations can follow: ranging from asymptomatic myocardial ischemia, sometimes referred to as silent ischemia, to myocardial infarction and even sudden cardiac death.
There is evidence that coronary artery spasm is caused by mutation in the nitric oxide (NO) synthase-3 gene (NOS3) on cytogenetic location 7q36.1 and genomic coordinates 7:150,991,017-151,014,588. The screenshot of the NOS3 gene 23,572 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides NOS3 in the 7q36.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:150,791,301 | TMEM176B | Transmembrane protein 176B |
| 7:150,800,769 | TEM176A | Transmembrane protein 176A |
| 7:150,852,120 | AOC1 | Amine oxidase, copper-containing, 1 |
| 7:150,944,961 | KCNH2 | Potassium voltage-gated channel, subfamily H, member 2 |
| 7:150,991,017 | NOS3 | Nitric oxide synthase 3, endothelial cell |
| 7:151,012,209 | ATG9B | Autophagy related 9B |
| 7:151,028,450 | ABCB8 | ATP-binding cassette, subfamily B, member 8 |
| 7:151,048,292 | ACCN3 | Cation channel, amiloride-sensitive, neuronal 3 |
| 7:151,053,815 | CDK5 | Cyclin-dependent kinase 5 |
| 7:151,058,200 | SLC4A2 | Solute carrier family 4, anion exchanger, member 2 |
