Here I present: “Hereditary Mixed Polyposis Syndrome”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HMPS1)
INTRODUCTION.
The hereditary mixed polyposis syndrome (HMPS1) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas.
There is evidence that hereditary mixed polyposis syndrome (HMPS1) can be caused by heterozygous duplication on chromosome 15q13-q14 that causes increased and ectopic expression of the germiin (GREM1) gene on genomic coordinates 15:27,800,001-39,800,000. The screenshot of the HMPS1 gene 12,000,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides HMPS1 in the 15q13-q14 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 15:26,971,181 | GABRG3 | Gamma-aminobutyric acid (GABA) A receptor, gamma-3 |
| 15:27,719,008 | OCA2 | oculocutaneous albinism II |
| 15:27,800,001 | B2MR | Beta-2-microglobulin regulator |
| 15:27,800,001 | CILD4 | Ciliary dyskinesia, primary, 4 |
| 15:27,800,001 | HMPS1 | Polyposis syndrome, hereditary mixed 1 |
| 15:27,800,001 | SCZD13 | Schizophrenia 13 |
| 15:27,800,001 | SRTD1 | Short-rib thoracic dysplasia 1 with or without polydactyly |
| 15:28,111,040 | HERC2 | HECT domain and RCC1-like domain 2 |
| 15:28,885,974 | APBA2 | Amyloid beta A4 precursor protein-binding, family A, member 2 |
| 15:29,117,712 | ENTREP2 | Endosomal transmembrane epsin interactor 2 |
