Genomic coordinate (human 11:64,803,513 MEN1).
Cytoband (human 11q13.1 MEN1).
Here I present: “MEN1 Pleiotropic Disorders”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (MEN1)
INTRODUCTION.
The six-phenotype pleiotropy set for menin tumor suppressor (MEN1) are:
1. Multiple endocrine neoplasia type-1 (MEN1 / Wermer syndrome) — the core syndrome, usually involving parathyroid, pituitary, and gastro-entero-pancreatic neuroendocrine tumors.
2. Familial isolated hyperparathyroidism (FIHP) — can result from MEN1 variants, often viewed as a milder or partial MEN1-expression state.
3. Primary hyperparathyroidism / parathyroid adenoma-hyperplasia phenotype — the most frequent MEN1-associated manifestation.
4. Pituitary adenoma phenotype — including prolactinomas and other anterior pituitary tumors.
5. Pancreatic / gastro-entero-pancreatic neuroendocrine tumor phenotype — including gastrinoma, insulinoma, and related NETs.
6. Adrenal endocrine tumor phenotype — adrenal lesions are recognized in MEN1, though they are less “classic” than the parathyroid-pituitary-pancreas triad.
There is evidence that the menin tumor suppressor (MEN1) gene pleiotropic for six-phenotype disorders is encoded on genomic coordinate 11:64,803,513 and cytoband 11q13.1 in humans.
