Here I present: “Streptococcal Immune-Antigen Suppression”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (ISCW) icd10=D84.9
INTRODUCTION.
Low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA-linked dominant gene which is designated as an immune suppression gene to the SCW antigen (ISCW) without knowing its function. An extended the study of the genetic control of the immune response to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness. Reported analysis of the function and expression of ISCW at the cellular level and demonstrate that the ISCW controls the generation of antigen-specific suppressor T cell in low responders.
There is evidence streptococcal immune-antigen suppression (ISCW) is caused by mutation in the gene on cytogenetic location 6p21.3 and genomic coordinates 6:30,500,001-36,600,000. The screenshot of the ISCW gene 6,100,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ISCW in the 6p21.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:30,500,001 | IGAD1 | Immunoglobulin A deficiency |
| 6:30,500,001 | IGAT | Immune response to synthetic polypeptide–IRGAT |
| 6:30,500,001 | IGLP1 | Immune response to synthetic polypeptides-1 |
| 6:30,500,001 | IGLP2 | Immune response to synthetic polypeptides-2 |
| 6:30,500,001 | ISCW | Immune suppression to streptococcal antigen |
| 6:30,500,001 | LAP | Laryngeal adductor paralysis |
| 6:30,500,001 | LATD | Laterality defects, autosomal dominant |
| 6:30,500,001 | LNCR4 | Lung cancer susceptibility 4 |
| 6:30,500,001 | MBNP | Membranous nephropathy, susceptibility to |
| 6:30,500,001 | MPVQTL4 | Mean platelet volume quantitative trait locus 4 |
