Here I present: “Tryptophan Oxygenase”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 色氨酸氧合酶 。(TRPO).
INTRODUCTION.
Congenital hypertryptophanemia, which is accompanied by hyperserotonemia, does not appear to have significant clinical consequences.
Metabolically, hypertryptophanemia results in tryptophanuria and exhibits significantly elevated serum levels of tryptophan, exceeding 650% of maximum (normal range: 25–73 micromole/l) in some instances.
Tryptophan oxygenase (EC. 1.13.11.11) plays a role in catalyzing the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
There is evidence that congenital hypertryptophanemia is caused by compound heterozygous mutation in the tryptophan oxygenase (TDO2) gene on cytogenetic location 4q32.1 and genomic coordinates 4:155,903,696-155,920,406 . The screenshot of the TDO2 gene 16,711 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides TDO2 in the 4q32.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 4:155,342,658 | ASAP | Aster-associated protein |
| 4:155,666,848 | GUCY1A1 | Guanylate cyclase 1, soluble, alpha 1 |
| 4:155,759,021 | GUCY1B1 | Guanylate cyclase 1, soluble, beta 1 |
| 4:155,829,729 | ASIC5 | Acid-sensing ion channel family member 5 |
| 4:155,903,696 | TDO2 | Tryptophan oxygenase |
| 4:155,924,118 | CTSO | Cathepsin O |
| 4:156,760,454 | PDGFC | Platelet-derived growth factor C |
| 4:157,076,150 | GLRB | Glycine receptor, beta subunit |
| 4:157,220,120 | GRIA2 | Glutamate receptor, ionotropic, AMPA 2 |
| 4:158,210,486 | TMEM144 | Transmembrane protein 144 |
