Here I present: “Parkinson Disease Susceptibility”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 家族性帕金森病。(PD).
INTRODUCTION.
Parkinson disease (PD) was first described by James Parkinson in 1817. It is the second most common neurodegenerative disorder after Alzheimer disease (AD) affecting approximately 1% of the population over age 50.
There is evidence evidence that late-onset or sporadic Parkinson disease (PD) can have more than one genetic and/or environmental cause including the ADH1C gene. The ADH1C gene encodes the gamma subunit of class I alcohol dehydrogenase (Enzyme Commission number # EC 1.1.1.1), an enzyme that catalyzes the rate-limiting step for ethanol metabolism: the oxidation of alcohol to acetaldehyde.
ADH1C is on cytogenetic location 4q23 and genomic coordinates 4:99,336,497-99,352,746. The screenshot of the ADH1C gene 16,250 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ADH1C in the 4q23 cytogenetic location are listed BENEATH. 
| Coordinate | Symbol | Genomic Name |
| 4:99,123,658 | ADH4 | Alcohol dehydrogenase (class II), pi polypeptide |
| 4:99,202,639 | ADH6 | Alcohol dehydrogenase 6 (aldehyde reductase) |
| 4:99,276,369 | ADH1A | Alcohol dehydrogenase IA (class I), alpha polypeptide |
| 4:99,304,971 | ADH1B | Alcohol dehydrogenase IB (class I), beta polypeptide |
| 4:99,336,497 | ADH1C | Alcohol dehydrogenase IC (class I) gamma peptide |
| 4:99,412,263 | ADH7 | Alcohol dehydrogenase-7 |
| 4:99,546,711 | TRMT10A | tRNA methyltransferase 10A |
| 4:99,564,130 | MTTP | Microsomal triglyceride transfer protein |
| 4:99,636,529 | C4orf54 | Chromosome 4 open reading frame 54 |
| 4:99,816,827 | DAPP1 | Dual adaptor phosphotyrosine 3-phosphoinositides 1 |
