Here I present: “Hot Water Epilepsy”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 熱水癲癇。(HWE2).
INTRODUCTION.
Hot water epilepsy (HWE) is a form of reflex or sensory epilepsy in which seizures are precipitated by immersion in hot water or pouring of hot water over the head during bathing. The seizures are usually complex partial, but about 33% of patients experience secondary generalization. There are no additional neurologic abnormalities.
Hot Water Epilepsy type-1 (HWE1) is located on chromosome ten (10); but, Hot Water Epilepsy type-2 (HWE2) is located on chromosome four (4) at cytogenetic location 4q24-q28 and genomic coordinates 4:100,100,001-138,500,000. The screenshot of the HWE2 gene 38,400,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides HWE2 in the 4q24-q28 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 4:99,816,827 | DAPP1 | Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 |
| 4:99,878,336 | LAMTOR3 | Late lysosomal adaptor, mitogen protein kinase and target of rapamycin 3 |
| 4:99,896,248 | DNAJB14 | DNAJ/HSP40 homolog, subfamily B, member 14 |
| 4:99,948,088 | H2AZ1 | H2A.Z variante histone 1 |
| 4:100,100,001 | HWE2 | Epilepsy, hot water, 2 |
| 4:100,100,001 | MGR1 | Migraine with or without aura, susceptibility to, 1 |
| 4:100,100,001 | OCA5 | Albinism, oculocutaneous, type V |
| 4:100,185,870 | DDIT4L | DNA damage-inducible transcript 4-like |
| 4:100,395,341 | EMCN | Endomucin |
| 4:101,023,418 | PPP3CA | Protein phosphatase 3, catalytic subunit, alpha isoform (calcineurin A alpha) |
