Here I present: “Complementation Group-C Xeroderma Pigmentosa”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 補體C組色素性外皮。(XPC).
INTRODUCTION.
Xeroderma pigmentosum (XP) is a genetically heterogeneous condition characterized by increased sensitivity to ultraviolet radiation (UV) and increased risk of skin cancer resulting from a defect in DNA repair. XPC (complementation-C XP) is the most common form of XP in the white populations, accounting for over a third of all cases in this group.
Complementation Group-C Xeroderma Pigmentosum (XPC), is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA adducts in nucleotide excision repair. It is located on cytogenetic location 3p25.1 and genomic coordinates 3:14,145,147-14,178,601. The screenshot of the XPC gene 33,455 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides XPC in the 3p25.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:13,816,258 | WNT7A | Wingless-type MMTV integration, member 7A |
| 3:13,937,307 | TPRXL | Tetrapeptide repeat homeobox-like |
| 3:14,112,077 | CHDH4 | Coiled-coil-helix-coiled-coil-helix protein 4 |
| 3:14,125,052 | TMEM43 | Transmembrane protein 43 |
| 3:14,145,147 | XPC | XPC complex subunit |
| 3:14,178,817 | LSM3 | LSM3 protein |
| 3:14,402,576 | SLC6A6 | Solute carrier family 6 member 6 |
| 3:14,651,762 | CCDC174 | Coiled-coil domain-containing protein 174 |
| 3:14,675,141 | C3orf20 | Chromosome 3 open reading frame 20 |
| 3:14,810,688 | FGD5 | FYVE, RhoGEF, and PH domain protein 5 |
