Here I present: “Thrombopoietin”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 血栓形成。(THPO).
INTRODUCTION.
Type-9 Thrombocytopenia,
Type-1 Thrombocythemia, and Type-2 Amegakaryocytic Thrombocytopenia are all three (3) caused by mutations in the megakaryocyte growth factor gene of Thrombopoietin (THPO) at genomic coordinates 3:184,371,935-184,379,688 in cytogenetic location 3q27.1 . The screenshot of the THPO gene 7,754 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides THPO in the 3q27.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:184,299,241 | PSMD2 | Proteasome 26S subunit, non-APTase, 2 |
| 3:184,314,606 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma, 1 |
| 3:184,346,185 | CLCN2 | Chloride channel-2 |
| 3:184,361,710 | POLR2H | Polymerase II, RNA, subunit H |
| 3:184,371,935 | THPO | Thrombopoietin (megakaryocyte growth factor) |
| 3:184,380,054 | CHRD | Chordin |
| 3:184,561,785 | EPHB3 | EPH-like tyrosine kinase-2 |
| 3:184,710,364 | MAGEF1 | Melanoma antigen, family F, 1 |
| 3:184,812,166 | VPS8 | VPS8, corvet complex subunit |
| 3:185,190,624 | EHHADH | Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase |
