Here I present: “Moyamoya Disease”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 莫亞莫亞病。もやもや病 。(MYMY1).
INTRODUCTION.
Spontaneous occlusion of the circle of Willis (Moyamoyaもやもや disease type-1, MYMY1) was first described by Japanese surgeons and is thought to have a high incidence in the Japanese population. MYMY1 is characterized by the angiographical findings of the obstructive vascular lesions around the terminal portions of the internal carotid arteries and the formation of abnormal vascular networks visualized in the arterial phase without any definite underlying conditions.
Moyamoya disease もやもや病 is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion associated with telangiectatic vessels in the region of the basal ganglia. The Japanese word moyamoya もやもやmeans ‘hazy like smoke in air.’
Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults.
The MYMY1 locus maps to cytogenetic location 3p26-p24.2 and genomic coordinates 3:1-26,300,000. The screenshot of the MYMY1 gene 26,300,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides MYMY1 in the 3p26-24.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:1 | CRCL | Creatinine clearance QTL |
| 3:1 | DEL3pterp25 | 3p- syndrome (chromosome 3pter-p25 deletion) |
| 3:1 | HPC5 | Prostate cancer, hereditary, 5 |
| 3:1 | IBD9 | Inflammatory bowel disease 9 |
| 3:1 | MYMY1 | Moyamoya disease |
| 3:1 | STQTL5 | Stature quantitative trait locus 5 |
| 3:196,763 | CHL1 | Cell adhesion molecule L1-like |
| 3:1,093,024 | CNTN6 | Contactin 6 |
| 3:2,098,866 | CNTN4 | Contactin 4 |
| 3:3,066,324 | IL5RA | Interleukin-5 receptor, alpha |
POSTLUDE.
Human body being one (1%) percent Nuclei Acid (shown in Table BELOW ) means I have approached my blog posts using Victor McKusick, Mendelian Inheritance in Man’, 1966. If you follow all of my blog posts regularly you will grasp the ”molecular biology of chromosomes” (one percent (1%) of the body).
