Here I present: “Anesthesia Malignant Hyperthermia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 麻醉恶性高热。(MH).
INTRODUCTION.
Anesthesia Malignant Hyperthermia (MH) is a potentially lethal pharmacogenetic disease for which MH susceptibility is transmitted as an autosomal dominant trait. A potentially life-threatening MH crisis is anesthesia triggered by exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants.
There is evidence malignant hyperthermia type-4 (MSH4) pharmacogenetic disease, is caused by the mutation in the MSH4 gene on cytogenetic location 3q13.1 and genomic coordinates 3:103,100,001-111,600,000. The screenshot of the MSH4 gene 8,500,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides MSH4 in the 3q13.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:101,724,614 | CEP97 | Centrosomal protein, 97kD |
| 3:101,827,990 | NFKBIZ | Nuclear factor kappa-B inhibitor, zeta |
| 3:102,385,144 | ZPLD1 | Zona pellucida-like domain-containing protein 1 |
| 3:103,100,001 | CHDS5 | Coronary heart disease, susceptibility to, 5 |
| 3:103,100,001 | MHS4 | Malignant hyperthermia susceptibility 4 |
| 3:105,366,909 | ALCAM | Activated leukocyte cell adhesion molecule |
| 3:105,655,461 | CBLB | CAS-BR-M ecotropic retroviral transform sequence B |
| 3:107,240,692 | DUBR | DPPA2 upstream-binding RNA, noncoding |
| 3:108,043,091 | CD47 | CD47 antigen (Rh-related antigen; integrin protein) |
| 3:108,160,812 | IFT57 | Intraflagellar transport 57 (HIP1 protein interactor) |
