Here I present: “Primary pulmonary Hypertension”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 原发性肺动脉高压.
INTRODUCTION.
Primary pulmonary hypertension type-1 (PPH1) is a condition of increased blood pressure in the arteries of the lungs. Symptoms include shortness of breath, fainting, tiredness, chest pain, swelling of the legs, and a fast heartbeat.
Bone morphogenetic protein (BMP) is a family of proteins that induce bone formation at extracellular sites in vivo. BMP act on osteoblasts and chondrocytes as well as other cell types, including neurocells, and they play important roles in embryonal development.
There is evidence that primary pulmonary hypertension type-1 (PPH1) is caused by heterozygous mutation in the bone morphogenetic protein receptor type-2 (BMPR2) gene on chromosome 2q33 and genomic coordinates 2:202,376,327-202,567,749 . The screenshot of the BMPR2 gene 191,423 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides BMPR2 in the 2q33 cytogenetic location are listed BENEATH. 
| Coordinate | Symbol | Genomic Name. |
| 2:201806429 | CDK15 | Cyclin-dependent kinase 15 |
| 2:202033855 | FZD7 | Frizzled class receptor 7 |
| 2:202206171 | SUMO1 | Small ubiquitin-like modifier 1 |
| 2:202265763 | NOP58 | NOP58 ribonucleoprotein |
| 2:202376327 | BMPR2 | Bone morphogenetic receptor, type II |
| 2:202874261 | WDR12 | WD repeat-containing protein 12 |
| 2:202912275 | ALS2CR8 | Amyotroph lateral sclerosis 2 chrom-region 8 |
| 2:203014608 | NBEAL1 | Neurobeachin-like 1 |
| 2:203328394 | ABI2 | ABL interactor 2 |
| 2:203433682 | RAPH1 | RAS association and pleckstrin homology 1 |
