Here I present: “Pre-Eclampsia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 子痫前期。
INTRODUCTION.
Pre-Eclampsia is a multi-system disorder specific to pregnancy, characterized by the new onset of high blood pressure and often a significant amount of protein in the urine or by the new onset of high blood pressure along with significant end-organ damage, with or without the proteinuria. When it arises, the condition begins after 20 weeks of pregnancy. In severe cases of the disease there may be red blood cell breakdown, a low blood platelet count, impaired liver function, kidney dysfunction, swelling, shortness of breath due to fluid in the lungs, or visual disturbances. Pre-Eclampsia increases the risk of undesirable as well as lethal outcomes for both the mother and the fetus including preterm labor. If left untreated, it may result in seizures at which point it is known as Eclampsia.
Pre-Eclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks’ gestation with clinically relevant proteinuria. Pre-Eclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide.
There is evidence Pre-Eclampsia type-1 is associated with mutation of the PEE1 gene on cytogenetic location 2p13 and genomic coordinates 2:68,400,001-74,800,000 . The screenshot of the PEE1 gene 6,400,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PEE1 on the 2p13 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 2:68,284,171 | CNRIP1 | Cannabinoid receptor-interact protein 1 |
| 2:68,365,282 | PLEK | Pleckstrin |
| 2:68,400,001 | OFC2 | Orofacial cleft 2 |
| 2:68,400,001 | PARK3 | Parkinson disease 3 |
| 2:68,400,001 | PEE1 | Preeclampsia/eclampsia 1 |
| 2:68,459,422 | FBXO48 | F-box protein 48 |
| 2:68,467,585 | AFPL | Aprataxin- and PNK-like factor |
| 2:68,643,579 | PROKR1 | Prokineticin receptor 1 |
| 2:68,710,544 | ARHGAP25 | RHO GTPase-activating protein 25 |
| 2:68,860,909 | BMP10 | Bone morphogenetic protein 10 |
