Here I present: “Anaplastic Lymphoma Kinase”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (ALK) 再生淋巴瘤激酶。
INTRODUCTION.
Anaplasia is a condition of cells with poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells. The term also refers to a group of morphological changes in a cell that point to a possible malignant transformation.
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor is an enzyme that in humans is encoded by the ALK gene on cytogenetic location 2p23.2-p23.1 and genomic coordinates 2:29,192,774-29,921,586 . The screenshot of ALK gene 728,813 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ALK in the 2p23.2-2p23.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 2:28,849,821 | TRMT61B | tRNA methyltransferase 61B |
| 2:28,894,667 | WDR43 | WD repeat-containing protein 43 |
| 2:28,956,518 | TOGARAM2 | TOG array regulator of axonemal microtubules 2 |
| 2:29,061,695 | PCARE | Photoreceptor cilium actin regulator |
| 2:29,192,774 | ALK | Anaplastic lymphoma kinase (Ki-1) |
| 2:30,147,007 | YPEL5 | Yippee-like 5 |
| 2:30,231,534 | LBH | LBH regulator of WNT signaling pathway |
| 2:30,447,246 | LCLAT1 | Lysocardiolipin acyltransferase 1 |
| 2:30,722,771 | CAPN13 | Calpain 13 |
| 2:30,886,782 | GALNT14 | Polypeptide N-acetylgalactosaminyltransferase 14 |
