Here I present: “Tumor Suppressor p53 Protein”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Tumor Suppressor p53 Protein encoded by the TP53 gene, is the most frequently mutated gene in cancer.
There is evidence that the tumor protein p53-binding protein-2 (TP53BP2) gene is on cytogenetic location 1q41 and genomic coordinates1:223,779,893-223,845,947 . The screenshot of the TP53BP2 gene 66,055 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides TP53BP2 in the 1q41 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 1:223,109,404 | TLR5 | Toll-like receptor-5 |
| 1:223,220,831 | SUSD4 | Sushi domain-containing protein 4 |
| 1:223,541,616 | CAPN8 | Calpain 8 |
| 1:223,701,597 | CAPN2 | Calpain, large polypeptide L2 |
| 1:223,779,893 | TP53BP2 | Tumor protein p53-binding protein-2 |
| 1:223,900,001 | BCC2 | Basal cell carcinoma, susceptibility to, 2 |
| 1:223,900,001 | EA3 | Episodic ataxia, type 3 |
| 1:223,900,001 | HRES1 | HTLV-1 related endogenous sequence |
| 1:223,900,001 | MDC1B | Muscular dystrophy, congenital, 1B |
| 1:223,900,001 | PEPC | Peptidase C |
