Nicolaus Copernicus, “On the Revolutions of Heavenly Spheres”, 1543; and, Andreas Vesalius, “On the Fabric of the Human Body”, 1543 are a pair of scientific books beginning the Scientific Revolution.
The Gutenberg Revolution was the printing of The Bible in vernacular languages, and not Latin (or Greek). In 1543 the printing of secular science books has changed the history of writings. The printing of navigational maps lead to Columbus’s discovery. Now in 1543 two books published by Copernicus and Vesalius demarcate the Scientific Revolution in books. Science Fiction books in earlier ages could be categorized as Fantasy. After 1543 science fiction and fantasy (fairytale) are different.