Genomic coordinate (human 12:10,907,926 TRB3).
Cytoband (human 12p13.2 TRB3).
Intraband%= 34.9% TRB3
OMIM’ genes @ 12p13.2 = 16 genes.
ClinVar = 102 TRB3 variants reported, 8 clinically significant.
Hyperbolic Umbilic Chromosome-12 is 1,200 genes.
Cytoband Position (0.1 = human 12p13.2).
Chromosome-12 Cytobands: WG₂[TRB3]B₂GC_CBG₅B₂G₆
Here I 🎁 present: “TRB3-Taste Receptor Bitterness”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (TRB3)
INTRODUCTION.
Taste receptors are specialized cellular proteins located primarily inside taste buds on the tongue. They detect chemical compounds in food and drink, allowing humans to perceive five basic’ tastes’: sweet, salty, sour, bitter, and savory.
The Five Basic’ Tastes’ and How They Work
Sweet: Uses G-protein coupled receptors (TAS1R2 and TAS1R3) to detect sugars and artificial sweeteners.
Bitter: Uses roughly 25 different TAS2R receptors to identify toxic or poisonous substances.
Savory: Uses TAS1R1 and TAS1R3 receptors to detect savory amino acids like glutamate.
Salty: Relies on ion channels (like epithelial sodium channels) to detect sodium ions.
Sour: Uses specialized proton channels (such as Otop1) to detect acidity and hydrogen ions.
