Genomic coordinate (human 10:86,755,753 BMPR1A) & (mouse 14:34,133,018 Bmpr1a).
Juvenile polyposis syndrome (JPS) is a hereditary condition identified by the presence of multiple polyps (abnormal growths or tumors) in the gastrointestinal (GI) tract. In JPS, the polyps are called juvenile or inflammatory polyps. The term “juvenile” refers to the type of polyp, not the age of when the polyps occur.
Juvenile polyposis syndrome is an autosomal dominant condition that predisposes gene carriers to various types of tumors. The diagnosis is based on the occurrence of hamartomatous gastrointestinal polyps that turn into malignant lesions in approximately 20% of cases.
Juvenile polyposis syndrome is an autosomal dominant genetic condition characterized by the appearance of multiple juvenile polyps in the gastrointestinal tract. Polyps are abnormal growths arising from a mucous membrane. These usually begin appearing before age 20, but the term juvenile refers to the type of polyp (benign hamartoma, as opposed to adenoma), not to the age of the affected person. While the majority of the polyps found in juvenile polyposis syndrome are non-neoplastic, hamartomatous, self-limiting and benign, there is an increased risk of adenocarcinoma.
There is evidence that juvenile polyposis syndrome is caused by mutation in bone morphogenetic protein receptor-1A (BMPR1A) gene encoded on genomic coordinate 10:86,755,753 and cytoband 10q23.2 in humans.
