Genomic coordinate (human 10:96,189,171 BLNK) & (mouse 19:40,917,371 Blnk).
Cytoband (human 10q24.1 BLNK) & (mouse 19qC3 Blnk).
Here I present: “Hypogammaglobulinemia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (BLKN) icd10=D80.1
PRELUDE: “Immune Syntax without Nouns”.
Memory is two types: neural (cranial & spinal), or molecular (genetic & immune). Memory indeed has two (2) grammars:
Neural memory → cranial & spinal inscriptions of experience.
Molecular memory → genetic inheritance and immune recognition.
When immune memory loses its nouns (B-cells, antibodies), the sentence of self versus non-self collapses into verbs without objects — action without reference.
When neural memory loses its symbols, thought becomes motion without meaning.
Two scripts.
One organism.
One syntax of survival.
INTRODUCTION.
Agammaglobulinemia is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
The two (2) most common forms of agammaglobulinemia are X-linked agammaglobulinemia (AGMX1) and autosomal agammaglobulinemia type-4 ( AGM4 ).
There is evidence that hypogammaglobulinemia type-4 (AGM4) is caused by mutation in the B-cell linker protein (BLNK) gene encoded on genomic coordinate 10:96,189,171 and cytoband 10q24.1 in humans.
