Genomic coordinate (human 10:87,863,625 PTEN) & (mouse 19:32,734,977 Pten).
Cytoband (human 10q23.31 PTEN) & (mouse 19qC1 Pten).
Here I present: “Glioblastoma Multiforme“, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PTEN) icd10=C71.0
INTRODUCTION.
Gliomas are central nervous system (CNS) neoplasms derived from glial cells and comprise astrocytomas, Glioblastoma Multiforme, oligodendrogliomas, ependymomas, and subependymomas. Glial cells can show various degrees of differentiation even within the same tumor.
Glioblastoma Multiforme.
Clinical Features
Typical presentation
Progressive headache
Seizures
Focal neurologic deficits (hemiparesis, aphasia, visual loss)
Cognitive or personality change
Signs of raised intracranial pressure
Imaging (MRI)
Ring-enhancing mass with central necrosis
Irregular margins
Marked vasogenic edema
Butterfly pattern if crossing corpus callosum
Clinical Behavior
Highly infiltrative
Rapid progression
Median survival ~12–15 months despite therapy
There is evidence that Glioblastoma Multiforme is caused by mutation in the phosphatase and tensin homolog (PTEN) gene encoded on genomic coordinate 10:87,863,625 and cytoband 10q23.31 in humans.
