Here I present: “Minimal Cell Physiology: 256 Essential Proteins.
INTRODUCTION.
When a student has learned 14 biochemical categories of the Prokaryote domain he has halfway complete. There are 28 human categories (Eukaryote domain). 256 essential proteins are the minimal cell physiology.
Human Proteinome (Eukaryote).
0. Unclassified: 23.6%
1. Transcription factors: 12.0%
2. Transferases: 8.8%
3. Nucleic acid binding: 8.5%
4. Transporters: 6.4%
5. Receptors: 6.3%
6. Signaling molecules: 5.6%
7. Enzyme modulators: 5.0%
8. Oxidoreductases: 3.2%
9. Proteases: 2.8%
10. Hydrolases: 2.6%
11. Cytoskeletal proteins: 2.6%
12. Membrane traffic proteins: 1.9%
13. Structural proteins: 1.6%
14. Ligases: 1.5%
15. Transfer/carrier proteins: 1.4%
16. Phosphatases: 1.3%
17. Chaperones: 0.8%
18. Defense/immunity proteins: 0.6%
19. Lyases: 0.6%
20. Isomerases: 0.5%
21. Transmembrane receptor regulatory/adaptor proteins: 0.5%
22. Cell adhesion molecules: 0.5%
23. Extracellular matrix protein: 0.4%
24. Cell junction proteins: 0.4%
25. Calcium-binding proteins: 0.4%
26. Surfactants: 0.1%
27. Storage proteins: 0.1%
28. Viral proteins: 0.01%
Prokaryote (Minimal Proteinome).
1. Translation 36.95%
2. Energy 13.22%
3. Nucleotide Metabolism 8.95%
4. Replication 7.00%
5. Other Conserved-Proteins 7.00%
6. Chaperone Function 5.06%
7. Transcription 3.50%
8. Recombination & Repair 3.11%
9. Coenzyme Metabolism 3.11%
10. Exopolysaccharides 3.11%
11. Amino Acid Metabolism 2.72%
12. Lipid Metabolism 2.34%
13. Inorganic-Ion Uptake 1.94%
14. Secretion, Receptor 1.94%
