Here I present: “Leukemia”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Chromosome nine (#9) has leukemia genes at: cytogenetic locations 9p21.3 & 9q34.12; and, genomic coordinates 9:20,341,669 & 9:130,902,440. The leukemia genes are MLLT3 & ABL1.
ABL1 and MLLT3 are both genes that can be altered in various types of leukemia, often through fusion with other genes.
The ABL1 gene is famous for its role in the BCR-ABL1 fusion gene, which is the hallmark of chronic myeloid leukemia and is also found in some other leukemias. The MLLT3 gene is frequently involved in gene fusion in leukemias, such as KMT2A-MLLT3 which is associated with certain types of acute lymphoblastic leukemia and acute myeloid leukemia.
