Genomic coordinate 8:124,474,880
Here I present: “Renal Cell Carcinoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (RFN139) 腎細胞癌icd10=C79.00
INTRODUCTION.
Renal cell carcinoma occurs nearly twice as often in men as in women; incidence in the United States is equivalent among whites and blacks. Cigarette smoking doubles the likelihood of renal cell carcinoma and contributes to as many as one-third of cases. Obesity is also a risk factor, particularly in women. Other risk factors include hypertension, unopposed estrogen therapy, and occupational exposure to petroleum products, heavy metals, or asbestos.
RING finger protein-139 is a protein that in humans is encoded by the RNF139 gene. The RNF139 protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in hereditary renal cell carcinoma.
Mutations in several genes have been demonstrated to lead to renal cell carcinoma including the RFN139 gene on cytogenetic location 8q24.13 and genomic coordinate 8:124,474,880. Nine (9) other genes besides RFN139 in the 8q24.13 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 8:123,680,794 | ANX13 | Annexin XIII |
| 8:123,851,987 | FER1L6 | FER1-like family, member 6 |
| 8:124,306,189 | TMEM65 | Transmembrane protein 65 |
| 8:124,450,820 | TRMT12 | tRNA methyltransferase 12 homolog |
| 8:124,474,880 | RNF139 | RING finger protein-139 |
| 8:124,488,494 | TATDN1 | TatD DNase domain-containing protein 1 |
| 8:124,539,123 | NDUFB9 | NADH-ubiquinone oxidoreductase subunit B9 |
| 8:124,550,784 | MTSS1 | MTSS I-BAR domain containing 1 protein |
| 8:124,998,505 | SQLE | Squalene epoxidase |
| 8:125,024,260 | WASHC5 | WASH complex, subunit 5 |
