Genomic coordinate 8:42,174,718
Here I present: “Plasminogen Activator Deficiency”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PLAT) 質原啟動劑缺乏症。icd10=E88.02
INTRODUCTION.
Tissue plasminogen activator (PLAT) gene is a serine protease (Enzyme Commission number EC# 3.4.21.68). One of the main functions of PLAT is to cleave and activate the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity.
There is evidence that tissue plasminogen activator (PLAT) is encoded on cytogenetic location 8p11.21 and genomic location 8:42,174,718. Nine (9) other genes besides PLAT in the 8p11.21 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 8:41,645,177 | NKX6-3 | NK6, Drosophila, homolog of |
| 8:41,653,225 | ANK1 | Ankyrin-1, erythrocytic |
| 8:41,929,479 | KAT6A | K(lysine) acetyltransferase 6A |
| 8:42,153,063 | AP3M2 | Adaptor-related protein complex 3, mu-2 |
| 8:42,174,718 | PLAT | Plasminogen activator, tissue type |
| 8:42,271,302 | IKBKB | Inhibitor of nuclear factor kappa-B kinase, beta |
| 8:42,338,494 | POLB | Polymerase (DNA directed), beta |
| 8:42,374,063 | DKK4 | Dickkopf WNT signaling pathway inhibitor 4 |
| 8:42,391,880 | VDAC3 | Voltage-dependent anion channel 3 |
| 8:42,416,475 | SLC20A2 | Solute carrier family 20, member 2 |
