Genomic coordinate 8:127,735,434
Here I present: “MYC-activation PVT-oncogene”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (MYC) icd10=D47.1
INTRODUCTION.
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three (3) related human genes: c-myc (MYCC), l-myc (MYCL), and n-myc (MYCN).
C-myc (also referred to as Myc) was the first gene to be discovered in this family.
Burkitt lymphoma is an aggressive B-cell lymphoma that accounts for 50% of lymphomas in children but only 2% of lymphomas in adults. It results from chromosomal translocations that involve the MYC gene and either the lambda or the kappa light chain immunoglobulin genes. Burkitt lymphoma is causally related to the Epstein-Barr virus although the pathogenetic mechanisms are not clear.
The MYC gene is on cytogenetic location 8q24.21, the breakpoint in Burkitt lymphoma translocations at genomic coordinate 8:127,735,434-127,742,951. The screenshot of the MYC gene 7,518 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides MYC in the 8q24.21 cytogenetic location are listed BENEATH. 
| Coordinate | Symbol | Genomic Name |
| 8:127,289,676 | CASC8 | Cancer susceptibility candidate 8, noncoding |
| 8:127,400,399 | CCAT2 | Colon cancer-associated transcript 2, noncoding |
| 8:127,413,447 | POU5F1B | POU domain, class 5, transcription factor 1B |
| 8:127,700,608 | CASC11 | Cancer susceptibility candidate 11, noncoding |
| 8:127,735,434 | MYC | MYC protooncogene, bHLH transcription factor |
| 8:127,794,524 | PVT1 | Pvt1 oncogene (MYC activator) |
| 8:129,351,694 | CCDC26 | CCDC26 long non-coding RNA |
| 8:129,705,435 | GSDMC | Gasdermin C |
| 8:129,839,593 | FAM149B | Family with sequence similarity 49, member B |
| 8:130,052,104 | ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
