Genomic coordinate 12:111,766,933
Here I present: “Acetaldehyde Dehydrogenase”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (ALDH2) 乙醛脫氫酶。icd10=T51.0
INTRODUCTION.
Acetaldehyde dehydrogenase (ALDH) (Enzyme Commission number EC 1.2.1.3) is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are 2 major ALDH isozymes in the liver: cytosolic ALDH1 and mitochondrial ALDH2.
There is evidence that alcohol intolerance is caused by mutation in the acetaldehyde dehydrogenase-2 (ALDH2) gene encoded on cytogenetic location 12q24.12 and genomic coordinates 12:111,766,933-111,817,532. The screenshot of the ALDH2 gene 50,600 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ALDH2 in 12q24.12 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 12:111,404,730 | SH2B3 | SH2B adaptor protein 3 |
| 12:111,452,214 | ATXN2 | Ataxin-2 |
| 12:111,642,146 | BRAP | BRCA1-associated protein |
| 12:111,686,053 | ACAD10 | Acyl-CoA dehydrogenase family, member 10 |
| 12:111,766,933 | ALDH2 | Aldehyde dehydrogenase 2 family, mitochondrial |
| 12:111,842,228 | MAPKAPK5 | Mitogen-activated protein kinase-activated protein kinase 5 |
| 12:112,013,426 | C12orf8 | Endoplasmic reticulum lumenal protein 28 |
| 12:112,026,689 | NAA25 | N-alpha-acetyltransferase 25, NatB auxiliary subunit |
| 12:112,125,560 | TRAFD1 | TRAF-type zinc finger domain-containing 1 |
| 12:112,160,195 | HECTD4 | HECT domain E3 ubiquitin protein ligase 4 |
