Genomic coordinate 8:133,237,175
Here I present: “Charcot-Marie-Tooth Neuropathy”, Victor McKusick, Mendelian Inheritance in Man’, 1966. シャルコート・マリー・トゥース神経障害。 icd10=G60.0
INTRODUCTION.
Charcot-Marie-Tooth disease type-4D (CMT4D) is an autosomal recessive disorder of the peripheral nervous system characterized by early-onset distal muscle weakness and atrophy, foot deformities, and sensory loss affecting all modalities. Affected individuals develop deafness by the third decade of life.
There is evidence Charcot-Marie-Tooth disease type-4D (CMT4D) is caused by homozygous mutation in the N-myc downstream-regulated gene-1 (NDRG1) gene on cytogenetic location 8q24.22 and genomic coordinates 8:133,237,175-133,297,252. The screenshot of the NDRG1 60,078 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides NDRG1 in the 8q24.22 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 8:132,866,958 | TG | Thyroglobulin |
| 8:133,036,728 | SLA | Src-like-adaptor |
| 8:133,054,959 | PTCSC1 | Papillary thyroid carcinoma susceptibility candidate 1 |
| 8:133,191,039 | CCN4 | Cellular communication netowrk factor 4 |
| 8:133,237,175 | NDRG1 | N-myc downstream-regulated gene 1 |
| 8:133,454,848 | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| 8:134,477,788 | ZFAT1 | Zinc finger gene in autoimmune thyroid disease 1 |
| 8:134,800,520 | MIR30B | Micro RNA 30B |
| 8:134,804,876 | MIR30D | Micro RNA 30D |
| 8:135,457,456 | KHDRBS3 | KH domain RNA-binding, signal protein 3 |
