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“Mutation”, Victor McKusick, Mendelian Inheritance in Man, 1966.

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Here I present: “Mutation”, Victor McKusick, Mendelian Inheritance in Man’, 1966.

INTRODUCTION.

The human chromosomal DNA vary in length from 248,956,422 (chromosome #1) to 46,709,983 (chromosome #21) bp (base pairs).  The lengths of each chromosome is shown ATOP.

The Genetic Code shown ABOVE is what is used to define  “mutation”, that is a “mutation” is an error in biological sequence.

 

The list of encoded amino acids is given BELOW.  The biological sequence of amino acids is primary structure (linear), but mutation sequences have secondary & ternary structure (spatial, nonlinear).  Molecular structure is what Victor McKusick, Mendelian Inheritance in Man’, 1966 is about, and my blog posts are about this book.

Amino Acid Side Group 
A Ala Alanine CH3
B   *
C Cys Cysteine CH2SH
D Asp Aspartate CH2COOH
E Glu Glutamate CH2CH2COOH
F Phe Phenylalanine CH2C6H5
G Gly Glycine H
H His Histidine CH2-C3H3N2
I Ile Isoleucine CH(CH3)CH2CH3
J   *
K Lys Lysine (CH2)4NH2
L Leu Leucine CH2CH(CH3)2
M Met Methionine CH2CH2SCH3
N Asn Asparagine CH2CONH2
O Pyl Pyrolysine (CH2)4NHCOC4H5NCH3
P Pro Proline CH2CH2CH2-
Q Gln Glutamine CH2CH2CONH2
R Arg Arginine (CH2)3NH-C(NH)NH2
S Ser Serine CH2OH
T Thr Threonine CH(OH)CH3
U Sec Selenocysteine CH2SeH
V Val Valine CH(CH3)2
W Trp Tryptophan CH2C8H6N
X   *
Y Try Tyrosine CH2-C6H4OH
Z   *

 

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