Here I present: “Chromosome #Y“, Victor McKusick, Mendelian Inheritance in Man’, 1966. 染色體 #Y。icd10=Q98.8
INTRODUCTION.
Victor McKusick, Mendelian Inheritance in Man’, 1966 gives a list for chromosome #Y of fifty-seven (57) genes listed BELOW. The ATOP thirteen (13) genes of chromosome #Y are commonly discussed.
Langer Mesomelic Dysplasia and Leri-Weill dyschondrostenosis of chromosome #Y is presented here.
Langer Mesomelic Dysplasia(LMD) is a congenital disorder characterized by altered bone formation, which typically causes affected individuals to experience shortening of the bones of the extremities as well as an abnormally short stature.
The disease is caused by mutations of the short-stature homeobox gene (SHOX), located at the pseudoautosomal region PAR1 of the human sex chromosomes, or this gene’s enhancer region. In other words, it is a genetic abnormality inherited in a recessive manner. Carrying only one mutant allele (heterozygosity) presents as Leri-Weill dyschondrostenosis.
| Coordinate | Symbol | Genomic Name |
| Y:1 | RPY | Retinitis pigmentosa, Y-linked |
| Y:1 | DFNY1 | Deafness, Y-linked 1 |
| Y:1 | PLCXD1Y | Phospholipase C, phosphatidylinositol-specific, X domain-containing protein 1 |
| Y:1 | XGR | XG regulator |
| Y:600,001 | DHRSY | Dehydrogenase/reductase, Y-linked |
| Y:624,344 | SHOXY | Short stature homeobox, Y-linked |
| Y:1,190,490 | CRLF2Y | Cytokine receptor-like factor 2, Y-linked |
| Y:1,268,814 | CSF2RY | Granulocyte-macrophage colony-stimulating factor receptor, alpha subunit |
| Y:1,336,785 | IL3RA | Interleukin-3 receptor (Y chromosome) |
| Y:1,386,152 | ANT3Y | Adenine nucleotide translocator-3 (Y chromosome) |
| Y:1,403,139 | ASMTLY | Acetylserotonin methyltransferase-like, Y-linked |
| Y:1,591,604 | AKAP17A | A kinase (PRKA) anchor protein 17A |
| Y:1,615,059 | ASMTY | Acetylserotonin methyltransferase (Y chromosome) |
| Y:2,691,295 | MIC2Y | Antigen identified by monoclonal 12E7, Y homolog |
| Y:2,786,855 | SRY | Sex-determining region Y (testis determining factor) |
| Y:2,841,602 | RPS4Y1 | Ribosomal protein S4, Y-linked, 1 |
| Y:2,935,381 | ZFY | Zinc finger protein, Y-linked |
| Y:3,579,067 | TGIF2LY | Transforming growth factor-beta-induced factor 2-like, Y-linked |
| Y:5,000,296 | PCDH11Y | Protocadherin 22 |
| Y:6,865,918 | AMELY | Amelogenin (Y chromosome) |
| Y:6,910,697 | TBL1Y | Transducin-beta-like 1, Y-linked |
| Y:7,273,972 | PRKY | Protein kinase, Y-linked |
| Y:9,466,955 | TSPY1 | Testis-specific protein, Y-linked, 1 |
| Y:10,400,001 | DELYq11 | Chromosome Yq11 interstitial deletion syndrome |
| Y:10,400,001 | HEY | Hairy ears, Y-linked |
| Y:12,662,352 | TTTY15 | Testis-expressed transcript, Y-linked, 15, noncoding |
| Y:12,701,231 | USP9Y | Ubiquitin-specific protease-9, Y chromosome |
| Y:12,903,999 | DDX3Y | DEAD-box helicase 3, Y-linked |
| Y:13,233,895 | UTY | Ubiquitously transcribed TPR gene on Y chromosome |
| Y:13,703,899 | TMSB4Y | Thymosin, beta-4, Y chromosome |
| Y:13,985,772 | VCY | Variably charged, Y chromosome |
| Y:14,056,227 | VCY1B | Variably charged, Y chromosome, 1B |
| Y:14,522,616 | NLGN4Y | Neuroligin 4, Y-linked |
| Y:17,768,980 | XKRY | XK-related protein on Y chromosome |
| Y:18,025,787 | CDY2 | Chromodomain protein, Y chromosome, 2 |
| Y:18,529,643 | HSFY | Heat shock transcription factor, Y-linked |
| Y:19,567,358 | TXLNGY | Taxilin gamma pseudogene, Y-linked |
| Y:19,703,865 | KDM5D | Lysine demethylase 5D |
| Y:20,575,776 | EIF1AY | Eukaryotic translation initiation factor 1A, Y isoform |
| Y:20,756,108 | RPS4Y2 | Ribosomal protein S4, Y-linked |
| Y:21,534,879 | RBMY1A1 | RNA binding motif protein, Y chromosome, family 1, member A1 |
| Y:22,071,706 | PRY2 | PTPBL-related gene on Y, 2 |
| Y:22,296,798 | TTTY5 | Testis-specific transcript, Y-linked, 5 |
| Y:22,439,593 | TTTY6 | Testis-specific transcript, Y-linked, 6 |
| Y:22,490,397 | PRY | PTPN13-like, Y-linked |
| Y:22,851,584 | TTY17 | Testis-specific transcript, Y-linked, 17 |
| Y:22,936,455 | TTTY4 | Testis-specific transcript, Y-linked, 4 |
| Y:22,984,263 | BPY2 | Basic protein on Y chromosome, 2 |
| Y:23,129,355 | DAZ1 | Deleted in azoospermia 1 |
| Y:23,219,457 | DAZ2 | Deleted in azoospermia 2 |
| Y:24,209,967 | GOLGA2P2Y | GOLGA2 pseudogene 2, Y-linked |
| Y:24,763,069 | DAZ3 | Deleted in azoospermia 3 |
| Y:24,833,820 | DAZ4 | Deleted in azoospermia 4 |
| Y:25,482,908 | CSPG4P1Y | Chondroitin sulfate proteoglycan 4 pseudogene 1, Y-linked |
| Y:25,622,115 | CDY1 | Chromodomain protein, Y chromosome |
| Y:25,728,490 | TTTY3 | Testis-specific transcript, Y-linked, 3 |
| Y:26,600,001 | GCY | Growth control, Y-chromosome influenced |
