Genomic coordinate 7: 80,602,207
Here I present: “Platelet Glycoprotein-IV Deficiency”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 血小板糖蛋白-IV缺乏。 icd10=D69.1
INTRODUCTION.
Platelet glycoprotein-IV deficiencyis a disorder characterized by macrothrombocytopenia without significant bleeding issues. It can be divided into two subgroups: type-I, where platelets and monocytes lack CD36 expression, and type-II, where platelets lack CD36 but monocytes have near-normal levels. Symptoms include variable bleeding tendency, thrombocytopenia, giant platelets, and prolonged bleeding times.
This disease is inherited in an autosomal recessive manner and is caused by mutations in the CD36 antigen gene on cytogenetic location 7q21.11 and genomic coordinates 7:80,602,207-80,679,274.
The screenshot the CD36 gene 77,068 bp (base pairs) of DNA sequence is shown BELOW. Nine (9) other genes besides CD36 in the 7q21.11 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:77,900,001 | STQTL11 | Stature quantitative trait locus 11 |
| 7:78,017,055 | MAGI2 | Membrane-associated guanylate kinase, WW and PDZ domains-containing, 2 |
| 7:80,134,831 | GNAI1 | Guanine nucleotide-binding protein alpha-inhibiting activity polypeptide-1 |
| 7:80,458,635 | GNAT3 | Guanine nucleotide-binding protein, alpha-transducing activity polypeptide 3 |
| 7:80,602,207 | CD36 | CD36 antigen (collagen type-I) |
| 7:80,742,538 | SEMA3C | Semaphorin 3C |
| 7:81,699,010 | HGF | Hepatic growth factor |
| 7:81,946,444 | CACNA2D1 | Calcium channel, voltage-dependent, alpha-2/delta subunit |
| 7:82,754,012 | PCLO | Piccolo, mouse, homolog of |
| 7:83,363,238 | SEMA3E | Semaphorin 3E |
