Genomic coordinate 7:80,602,207
Here I present: “Platelet Glycoprotein-IV Deficiency”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (CD36) 血小板糖蛋白-IV缺乏。icd10=D69.1
INTRODUCTION.
Platelet glycoprotein-IV (CD36) deficiency can be divided into 2-types.
The type-I platelet glycoprotein-IV phenotype is characterized by platelets and monocytes/macrophages exhibiting CD36 deficiency; indeed no cells express CD36.
The type-II platelet glycoprotein-IV phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
There is evidence platelet glycoprotein-IV (CD36) deficiency is caused by homozygous or compound heterozygous mutation in the CD36 antigen gene on cytogenetic location 7q21.11 and genomic coordinates 7:80,602,207-80,679,274. The screenshot of the CD36 gene 77,068 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides CD36 in the 7q21.11 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:77,900,001 | STQTL11 | Stature quantitative trait locus 11 |
| 7:78,017,055 | MAGI2 | Membrane-associated guanylate kinase, WW and PDZ, 2 |
| 7:80,134,831 | GNAI1 | Guanine nucleotide-binding protein alpha-inhibiting activity polypeptide-1 |
| 7:80,458,635 | GNAT3 | Guanine nucleotide-binding protein, alpha-transducing activity polypeptide 3 |
| 7:80,602,207 | CD36 | CD36 antigen (collagen type I) |
| 7:80,742,538 | SEMA3C | Semaphorin 3C |
| 7:81,699,010 | HGF | Hepatic growth factor |
| 7:81,946,444 | CACNA2D1 | Calcium channel, voltage-dependent, alpha-2/delta subunit |
| 7:82,754,012 | PCLO | Piccolo, mouse, homolog of |
| 7:83,363,238 | SEMA3E | Semaphorin 3E |
