Here I present: “Glioblastoma Amplified Sequence”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (GBAS) 膠質母細胞瘤擴增序列。icd10=C71.9.
INTRODUCTION.
Cytogenetic location 7p11.2 is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system (CNS) tumors.
Glioblastoma Amplified Sequence (GBAS) is 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS is a member of the NIPSNAP gene family and designated it nipsnap homolog type-2 (NIPSNAP2) and is on cytogenetic location 7p11.2 and genomic coordinates 7:55,964,585-56,000,179. The screenshot of the NIPSNAP2 gene 35,595 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides NIPSNAP2 in cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:55,764,797 | PSPHP1 | Phosphoserine phosphatase pseudogene 1 |
| 7:55,793,540 | 14-Sep | Septin 14 |
| 7:55,887,456 | ZNF713 | Zinc finger protein 713 |
| 7:55,951,877 | MRPS17 | Mitochondrial ribosomal protein S17 |
| 7:55,964,585 | NIPSNAP2 | Nipsnap homolog 2 |
| 7:56,011,064 | PSPH | Phosphoserine phosphatase |
| 7:56,051,765 | CCT6A | Chaperonin containing T-complex polypeptide 1, subunit 6A |
| 7:56,064,286 | SUMF2 | Sulfatase-modifying factor 2 |
| 7:56,080,295 | PHKG1 | Phosphorylase kinase, gamma 1, muscle |
| 7:56,101,573 | CHCHD2 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 |
