Here I present: Hamilton Smith, “Nucleotide Sequence Specificity of Restriction Endonucleases”, NOBEL PRIZE LECTURE, 8 December 1978.
INTRODUCTION.
Werner Arber, Hamilton Smith & Daniel Nathans shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonuclease which enhanced the techniques of recombinant DNA (rDNA) technology.
A restriction enzyme is a DNA-enzyme that cleaves DNA into fragments at nucleotide specific recognition sequences within DNA-molecules. Restriction recognition sites are locations on a DNA molecule containing specific (4-8 base pairs in length) sequences of nucleotides.
Arber-Smith-Nathans 1978 NOBEL PRIZE LECTURES were the beginning of the recombinant DNA (rDNA) technology. EcoRI and EcoRII restriction enzymes among others are listed BELOW from the Hamilton Nathan’s NOBEL PRIZE LECTURE.
Hindsight is twenty-twenty (20-20) vision, and Hamilton Smith, “Nucleotide Sequence Specificity of Restriction Endonucleases”, NOBEL PRIZE LECTURE, 8 December 1978 was a historic advancement in molecular genetics.
