Here I present: “Diffuse Panbronchiolitis”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (DPB) 瀰漫性泛細支氣管炎。icd10=J21.9
INTRODUCTION.
Diffuse panbronchiolitis (DPB) is an inflammatory lung disease of unknown cause. It is a severe, progressive form of bronchiolitis, an inflammatory condition of the bronchioles (small air passages in the lungs). The term diffuse signifies that lesions appear throughout both lungs, while panbronchiolitis refers to inflammation found in all layers of the respiratory bronchioles (those involved in gas exchange). DPB causes severe inflammation and nodule-like lesions of terminal bronchioles, chronic sinusitis, and intense coughing with large amounts of sputum production.
There is evidence that diffuse panbronchiolitis is caused by mutation in the diffuse panbronchiolitis (PBLT) gene on 6p21.3 cytogenetic location and genomic coordinates 6:30,500,001-36,600,000. The screenshot of the PBLT gene 6,100,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PBLT in the 6p21.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:30,500,001 | NKS1 | Susceptibility to lysis by alloreactive natural killer cells |
| 6:30,500,001 | NPCA2 | Nasopharyngeal carcinoma, susceptibility to, 2 |
| 6:30,500,001 | PBC2 | Biliary cirrhosis, primary, 2 |
| 6:30,500,001 | PBCA | Pancreatic beta cell, agenesis of |
| 6:30,500,001 | PBLT | Panbronchiolitis, diffuse |
| 6:30,500,001 | PDCOS | Podoconiosis, susceptibility to |
| 6:30,500,001 | RLS6 | Restless legs syndrome, susceptibility to, 6 |
| 6:30,500,001 | RWS | Ragweed sensitivity |
| 6:30,500,001 | VAMAS6 | Vitiligo-associated multiple autoimmune disease susceptibility 6 |
| 6:30,500,001 | ZNF204 | Zinc finger protein-204 |
