“Opioid Receptors”, Victor McKusick, Mendelian Inheritance in Man, 1966. icd10=F11.1

 

Here I present: “Opioid Receptors”, Victor McKusick, Mendelian Inheritance in Man’, 1966. icd10=F11.1

INTRODUCTION.

Opioid receptors are a group of inhibitory G protein-coupled receptors with endogenous opioids as ligands. 

Endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. 

Opioid receptors are distributed widely in the brain, in the spinal cord, on peripheral neurons.

 

The OPRM1 gene encodes the Mu-opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin  and the enkephalins.  The OPRM1 receptor is a member of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa (OPRK1) and delta (OPRD1) each with a distinct pharmacologic profile.

There is evidence that the Mu-opioid receptor gene (OPRM1) is encoded on cytogenetic location 6q25.2 and genomic coordinates 6:154,010,496-154,246,867. The screenshot of the OPRM1 gene 236,372 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides OPRM1 in the 6q25.2 cytogenetic location are listed BENEATH.

 

 

 

 

Coordinate	Symbol	Genomic Name
6:152,750,797	VIP	Vasoactive intestinal peptide
6:152,970,535	FBXO5	F-box only protein 5
6:152,987,362	MTRF1L	Mitochondrial translational release factor 1-like
6:153,004,459	RGS17	Regulator of G protein signaling 17
6:154,010,496	OPRM1	Opioid receptor, mu-1
6:154,154,496	IPCEF1	Interaction protein for cytohesin exchange factors 1
6:154,387,515	CNKSR3	CNKSR family, member 3
6:154,733,378	SCAF8,l	SR-related C-terminal domain-associated factor 8
6:154,995,315	TIAM2	T-cell lymphoma invasion and metastasis 2
6:155,200,001	CELIAC12	Celiac disease, susceptibility to, 12