Here I present: “Multiple Myeloma Oncogene”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (IRF4) 多發性骨髓瘤。icd10=C90.0
INTRODUCTION.
MUM1 (multiple myeloma oncogene-1)/IRF4 (interferon regulatory factor-4) is a transcription regulatory factor that is activated as a result of t(6;14)(p25;q32) in multiple myeloma. MUM1 expression is seen in various B-cell lymphomas/leukemias and has been reported to predict an unfavorable outcome in some lymphoma subtypes including diffuse large B-cell lymphoma (DLBCL) and B-cell chronic lymphocytic leukemia (B-CLL).
There is evidence that multiple myeloma oncogene (MUM1) is encoded on the interferon regulatory factor-4 (IRF4) gene on cytogenetic location 6p25.3 and genomic coordinates 6:391,752-411,443. The screenshot of the IRF4 gene 19,692 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides IRF4 in the 6p25.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:1 | DEL6pter | Chromosome 6pter-p24 deletion syndrome |
| 6:1 | INTLQ3 | Intelligence quantitative trait locus 3 |
| 6:1 | LRSL | Larsen-like syndrome |
| 6:292,487 | DUSP22 | Dual-specificity phosphatase 22 |
| 6:391,752 | IRF4 | Interferon regulatory factor-4 |
| 6:485,154 | EXOC2 | Exocyst complex component 2 |
| 6:655,939 | HUS1B | HUS1 checkpoint clamp component B |
| 6:1,312,098 | FOXQ1 | Forkhead box Q1 |
| 6:1,389,576 | FOXF2 | Forkhead box F2 |
| 6:1,605,531 | FOXCUT | FOXC1 upstream transcript, noncoding |
