Here I present: “Immune Interferon Receptor”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (IFNGR1) 免疫干扰素受体。icd10=R76.12
INTRODUCTION.
Interferons may be regarded as polypeptide hormones because of their role in communicating from cell to cell a specific set of instructions that lead to a wide variety of effects.
Viruses induce type I interferon, subdivided into alpha-interferon (IFNA1) produced by leukocytes or lymphoblastoid cells, and beta-interferon (IFNB1) produced by fibroblasts.
Mitogens and antigenic stimuli induce in lymphocytes type II, immune, or gamma-interferon (IFNG). The biologic effects of human interferons, including increment of histocompatibility antigens, are mediated through species-specific receptors. The human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit.
There is evidence interferon receptor gamma (INFGR1) is encoded on cytogenetic location 6q23.3 and genomic coordinates 6:137,197,484-137,219,385. The screenshot of the INFGR1 gene 21,902 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides INFGR1 on the 6q23.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:136,822,592 | PEX7 | Peroxisomal biogenesis factor-7 |
| 6:136,922,301 | SLC35D3 | Solute carrier family 35, member D3 |
| 6:136,999,971 | IL20RA | Interleukin 20 receptor, alpha |
| 6:137,143,820 | IL22BP | Interleukin 22-binding protein |
| 6:137,197,484 | IFNGR1 | Immune interferon, receptor for |
| 6:137,492,199 | OLIG3 | Oligodendrocyte lineage transcription factor 3 |
| 6:137,823,669 | WAKMAR2 | Wound- and keratinocyte migration-associated long noncoding RNA 2 |
| 6:137,866,349 | TNFAIP3 | Tumor necrosis factor-alpha-induced protein 3 |
| 6:138,088,505 | PERP | p53 effector related to PMP22 |
| 6:138,161,939 | ARFGEF3 | ADP-ribosylation factor guanine nucleotide exchange factor 3 |
