Here I present: “Coronary Artery Disease”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (TCF21) 冠狀動脈疾病。icd10=I25.1
INTRODUCTION.
Transcription factor-21 (TCF21), also known as Epicardin, capsuling, or epicardin, is a protein that in humans is encoded by the Epicardin (TCF21) gene on chromosome-6. It is ubiquitously expressed in many tissues and cell types and highly significantly expressed in lung and placenta. Epicardin (TCF21) is crucial for the development of a number of cell types during embryogenesis of the heart, lung, kidney. and spleen. Epicardin (TCF21) is also deregulated in several types of cancers and thus known to function as a tumor suppressor. The Epicardin (TCF21) gene also contains one of 27 SNPs associated with increased risk of coronary artery disease (CAD).
There is evidence that coronary artery disease (CAD) caused by transcription factor-21 (TCF21) is due mutation on cytogenetic location 6q23.3 and genomic coordinates 6:133,889,113-133,895,537. The screenshot of the TCF21 gene 6,425 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides TCF21 in the 6q23.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:132,769,370 | C6orf192 | Chromosome 6 open reading frame 192 |
| 6:132,814,569 | RPS12 | Ribosomal protein S12 |
| 6:133,240,593 | EYA4 | EYA transcriptional coactivator and phosphatase 4 |
| 6:133,502,252 | TARID | TCF21 antisense RNA inducing promoter demethylation |
| 6:133,889,113 | TCF21 | Transcription factor-21 (epicardin; podocyte-expressed 1) |
| 6:133,952,174 | TBPL1 | TATA box-binding protein-like protein 1 |
| 6:133,987,581 | SLC2A12 | Solute carrier family 2 member 12 |
| 6:134,169,256 | SGK1 | Serum/glucocorticoid-regulated kinase 1 |
| 6:134,700,001 | MPVQTL5 | Mean platelet volume quantitative trait locus 5 |
| 6:134,917,393 | ALDH8A1 | Aldehyde dehydrogenase 8 family, member A1 |
