Here I present: “X-ray Repair”, Victor McKusick, Mendelian Inheritance in Man’, 1966. X光修復。(XRCC4) icd10=W88.0XXA
INTRODUCTION.
Eukaryotes use at least 2 pathways to repair DNA double-strand breaks: homologous recombination and nonhomologous end joining (NHEJ). The core NHEJ machinery includes XRCC4, DNA ligase IV (LIG4), and the DNA-dependent protein kinase complex, which consists of the DNA end-binding Ku70 (G22P1)/Ku80 (XRCC5) heterodimer and the catalytic subunit PRKDC.
There is evidence X-ray repair-cross complementing-4 (XRCC4) is encoded on cytogenetic location 5q14.2 and genomic coordinates 5:83,077,547-83,374,473. The screenshot of the XRCC4 gene 296,927 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides XRCC4 in the 5q14.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 5:81,233,322 | CKMT2 | Creatine kinase, mitochondrial-2 (sarcomeric) |
| 5:81,301,587 | ZCCHC9 | Zinc finger CCHC domain-containing protein 9 |
| 5:81,308,609 | ACOT12 | Acyl-CoA thioesterase 12 |
| 5:81,412,804 | SSBP2 | Single-stranded DNA-binding protein 2 |
| 5:81,972,023 | ATG10 | Autophagy related 10 |
| 5:82,100,001 | VUR4 | Vesicoureteral reflux 4 |
| 5:82,273,320 | RPS23 | Ribosomal protein S23 |
| 5:83,052,846 | TMEM167A | Transmembrane protein 167A |
| 5:83,064,204 | SCARNA18 | Small cajal body-specific RNA 18 |
| 5:83,077,547 | XRCC4 | X-ray repair cross complementing 4 |
