Here I present: “Malignant Hyperthermia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 惡性熱療。(MH).
INTRODUCTION.
Malignant hyperthermia (MH) is a life threatening disorder triggered in susceptible individuals on exposure to commonly used inhalational anaesthetics, e.g., halothane and the depolarizing muscle relaxant suxamethonium (succinyl choline).
Susceptibility to malignant hyperthermia (MH), a skeletal muscle disorder most often inherited as an autosomal dominant trait, is one of the main causes of death due to anesthesia.
There is evidence malignant hyperthermia type-6 is caused by a mutation in the MHS6 on cytogenetic location 5p and genomic coordinates 5:1-48,800,001. The screenshot of the MHS6 gene 48,800,001 bp (base pairs) of DNA sequence length is shown BELOW. Eight (8) other genes besides MHS6 in the 5p cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 5:1 | ASD1 | Atrial septal defect 1 |
| 5:1 | BCC3 | Basal cell carcinoma, susceptibility to, 3 |
| 5:1 | GLM8 | Glioma susceptibility 8 |
| 5:1 | LNCR3 | Lung cancer susceptibility 3 |
| 5:1 | MHS6 | Malignant hyperthermia susceptibility 6 |
| 5:1 | MYP16 | Myopia 16 |
| 5:1 | TST2 | Tuberculin skin test reactivity quantitative trait locus |
| 5:92,168 | PLEKHG4B | Pleckstrin RhoGEF domain-containing protein G4B |
| 5:218,320 | SDHA | Succinate dehydrogenase, flavoprotein subunit A |
