“Dyslexia Type-2”, Victor McKusick, Mendelian Inheritance in Man, 1966. 2型閱讀障礙。icd10=F81.0 (DYX2).

Here I present: “Dyslexia Type-2”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 2型閱讀障礙。icd10=F81.0 (DYX2).

INTRODUCTION.

Dyslexia (DYX) is a disorder manifested by difficulty learning to read despite conventional instruction, adequate intelligence, and sociocultural opportunity. It is the most common neurodevelopmental disorders, with a prevalence of 5 to 12%. Although there is evidence for familial clustering and heritability, the disorder is considered a complex multifactorial trait.

Developmental​ ​Cognitive​ ​Disability​ ​(DCD) and Emotional​ ​Behavioral​ ​Disability​ ​(EBD) are not Specific​ ​Learning​ ​Disability​ ​(SLD) all of which are listed BELOW.

Developmental​ ​Cognitive​ ​Disability​ ​(DCD):

F70​ ​–​ ​Mild​ ​intellectual​ ​disabilities

F71​ ​–​ ​Moderate​ ​intellectual​ ​disabilities

F72​ ​–​ ​Severe​ ​intellectual​ ​disabilities

F73​ ​–​ ​Profound​ ​intellectual​ ​disabilities

F78​ ​–​ ​Other​ ​intellectual​ ​disabilities

F79​ ​–​ ​Unspecified​ ​intellectual​ ​disabilities

Specific​ ​Learning​ ​Disability​ ​(SLD):

F81.0​ ​–​ ​Specific​ ​reading​ ​disorder

F81.1​ ​–​ ​Specific​ ​spelling  ​disorder

F81.2​ ​–​ ​Mathematics​ ​disorder

F81.81​ ​–​ ​Disorder​ ​of​ ​written​ ​expression

F81.89​ ​–​ ​Other​ ​developmental​ ​disorders​ ​of​ ​scholastic​ ​skills

F81.9​ ​–​ ​Developmental​ ​disorder​ ​of​ ​scholastic​ ​skills,​ ​unspecified

 

Emotional​ ​Behavioral​ ​Disability​ ​(EBD):

F88​ ​–​ ​Other​ ​disorders​ ​of​ ​psychological​ ​development

F89​ ​–​ ​Unspecified​ ​disorder​ ​of​ ​psychological​ ​development

F90.0​ ​–​ ​Attention-deficit​ ​hyperactivity​ ​disorder,​ ​predominantly​ ​inattentive​ ​type

F90.1​ ​–​ ​Attention-deficit​ ​hyperactivity​ ​disorder,​ ​predominantly​ ​hyperactive​ ​type

F90.2​ ​–​ ​Attention-deficit​ ​hyperactivity​ ​disorder,​ ​combined​ ​type

F90.8​ ​–​ ​Attention-deficit​ ​hyperactivity​ ​disorder,​ ​other​ ​type

F90.9​ ​–​ ​Attention-deficit​ ​hyperactivity​ ​disorder,​ ​unspecified  

There is evidence that variation in the dyslexia type-2 gene may be the basis of the form of dyslexia type-2 (DYX2) that maps to cytogenetic location 6p22-p21 and genomic coordinates 6:15,200,001-46,200,000. The screenshot of the DYX2 gene 31,000,000 bp (base pairs) of DNA sequence length is shown BELOW.  Nine (9) other genes besides DYX2 in the 6p22-p21 cytogenetic location are listed BENEATH.

 

 

 

Coordinate	Symbol	Genomic Name
6:15,200,001	ALPQTL3	Alkaline phosphatase, plasma level of, QTL 3
6:15,200,001	BWQTL4	Birth weight quantitative trait locus 4
6:15,200,001	CIHL	Hearing loss, cisplatin-induced, susceptibility to
6:15,200,001	CMAHP	Cytidine monophospho-N-acetylneuraminic acid hydroxylase pseudogene
6:15,200,001	DYX2	Dyslexia, susceptibility to, 2
6:15,200,001	NBLST4	Neuroblastoma, susceptibility to, 4
6:15,200,001	OTSC3	Otosclerosis 3
6:15,246,069	JARID2	Jumonji and AT-rich interaction domain containing 2
6:15,522,807	DTNBP1	Dystrobrevin-binding protein 1 (dysbindin)
6:16,129,086	MYLIP	Myosin regulatory light chain-interacting protein